Study Design  A prospective, randomized, controlled pilot study.

Setting  An accredited ambulatory facial plastic surgery center.

Patients  Healthy volunteer women (N = 8) undergoing rhytidectomy.

Intervention  Unilateral autologous platelet-rich plasma wound treatment during standard deep-plane rhytidectomy.

Main Outcome Measures  Staged postoperative facial photographs were graded in a blinded fashion by 3 facial plastic surgeon reviewers for postoperative ecchymosis and edema. Each facial side treated with APG that demonstrated less edema or ecchymosis than the non–APG-treated side was designated a positive response; otherwise, the response was equal (no difference) or negative (untreated side had less edema or ecchymosis).

Results  Twenty-one positive and 21 equal responses were observed compared with 8 negative ones. Of 20 unanimous observations, 15 were positive, only 3 equal, and 1 negative.